DBCO-C6-acid
DBCO-C6-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . DBCO-C6-acid can be used in the synthesis of carmaphycin analogues[1]. DBCO- C6- acid is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
Product Specifications
CAS Number
[1425485-72-8]
UNSPSC
12352203
Hazard Statement
H315, H319, H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dbco-c6-acid.html
Purity
98.89
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(CCCCC(O)=O)N1CC2=C(C=CC=C2)C#CC3=C1C=CC=C3
Molecular Formula
C21H19NO3
Molecular Weight
333.39
Precautions
H315, H319, H335
References & Citations
[1]Almaliti J, et al. Exploration of the carmaphycins as payloads in antibody drug conjugate anticancer agents.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Non-cleavable Linker
Available Sizes
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