Bupivacaine (hydrochloride)

Bupivacaine hydrochloride is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine hydrochloride can be used for the research of chronic pain[1][2][3].

Product Specifications

CAS Number

[18010-40-7]

UNSPSC

12352005

Hazard Statement

H300, H310, H330

Target

Calcium Channel; iGluR; Potassium Channel; Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Bupivacaine-hydrochloride.html

Purity

99.85

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(C1N(CCCC)CCCC1)NC2=C(C)C=CC=C2C.Cl

Molecular Formula

C18H29ClN2O

Molecular Weight

324.89

Precautions

H300, H310, H330

References & Citations

[1]Casati A, et, al. Bupivacaine, levobupivacaine and ropivacaine: are they clinically different? Best Pract Res Clin Anaesthesiol. 2005 Jun;19 (2) :247-68.|[2]Dan J, et, al. Inhibition of gastric cancer by local anesthetic bupivacaine through multiple mechanisms independent of sodium channel blockade. Biomed Pharmacother. 2018 Jul;103:823-828.