Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Prezalumab

Prezalumab (AMG 557) is a humanized IgG2 monoclonal antibody targeting ICOSL. Prezalumab inhibits T cell activation and related immune responses by binding to ICOSL and blocking the interaction between ICOS and ICOSL. Prezalumab can be used in the research of autoimmune diseases and inflammatory diseases such as systemic lupus erythematosus. Recommend Isotype Controls: Human IgG2 kappa, Isotype Control[2].

Product Specifications

CAS Number

1523164-68-2

Product Name Alternative

AMG 557

UNSPSC

12352203

Target

Interleukin Related; Transmembrane Glycoprotein

Type

Inhibitory Antibodies

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/prezalumab.html

Purity

99.23

Solubility

10 mM in DMSO

Smiles

[Prezalumab]

Molecular Weight

(145.5 kDa)

References & Citations

[1]Dillon SR, et al. Non-Redundant Roles of T Cell Costimulation Pathways in Inflammatory Arthritis Revealed by Dual Blockade of ICOS and CD28 with Acazicolcept (ALPN-101) . Arthritis Rheumatol. 2023 Aug;75 (8) :1344-1356.|[2]Cheng LE, et al. Brief Report: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Multiple-Dose Study to Evaluate AMG 557 in Patients With Systemic Lupus Erythematosus and Active Lupus Arthritis. Arthritis Rheumatol. 2018 Jul;70 (7) :1071-1076.

Shipping Conditions

Dry Ice

Storage Conditions

Store at -80°C for 2 years

Scientific Category

Inhibitory Antibodies

Clinical Information

Phase 2

Isoform

IL-13; IL-17

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Human MMP-1 (Matrix Metalloproteinase 1) QuickTest ELISA Kit
MBS7618332-01 48 Well

Human MMP-1 (Matrix Metalloproteinase 1) QuickTest ELISA Kit

Sign In for Pricing
View Details
Human MMP-1 (Matrix Metalloproteinase 1) QuickTest ELISA Kit
MBS7618332-02 96 Well

Human MMP-1 (Matrix Metalloproteinase 1) QuickTest ELISA Kit

Sign In for Pricing
View Details
Human MMP-1 (Matrix Metalloproteinase 1) QuickTest ELISA Kit
MBS7618332-03 5x 96 Well

Human MMP-1 (Matrix Metalloproteinase 1) QuickTest ELISA Kit

Sign In for Pricing
View Details
Human MMP-1 (Matrix Metalloproteinase 1) QuickTest ELISA Kit
MBS7618332-04 10x 96 Well

Human MMP-1 (Matrix Metalloproteinase 1) QuickTest ELISA Kit

Sign In for Pricing
View Details
Rabbit Ki-67 antibody, clone SQab1897 (monoclonal)
orb2302870 100 µL

Rabbit Ki-67 antibody, clone SQab1897 (monoclonal)

Sign In for Pricing
View Details
6-Bromonaphthalen-1-amine
OR78214-01 100 mg

6-Bromonaphthalen-1-amine

Sign In for Pricing
View Details