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AN5777

AN5777 is a GSPT1 degrader. AN5777 significantly reduces GSPT1 through the ubiquitin-proteasome system. AN5777 induces G1 block and Apoptosis. AN5777 has antitumor activity [1].

Product Specifications

CAS Number

491586-42-6

UNSPSC

12352005

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/an5777.html

Purity

98.37

Solubility

10 mM in DMSO

Smiles

CC1=C(N=C(C)C(C(N/N=C/C2=CC=CC=C2O)=O)=C3)C3=CC=C1

Molecular Formula

C19H17N3O2

Molecular Weight

319.36

References & Citations

[1]Zhang S, et al. Identification of novel GSPT1 degraders by virtual screening and bioassay. Eur J Med Chem. 2024 Jul 5;273:116524.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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