AN5777
AN5777 is a GSPT1 degrader. AN5777 significantly reduces GSPT1 through the ubiquitin-proteasome system. AN5777 induces G1 block and Apoptosis. AN5777 has antitumor activity [1].
Product Specifications
CAS Number
[491586-42-6]
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/an5777.html
Purity
98.37
Solubility
10 mM in DMSO
Smiles
CC1=C(N=C(C)C(C(N/N=C/C2=CC=CC=C2O)=O)=C3)C3=CC=C1
Molecular Formula
C19H17N3O2
Molecular Weight
319.36
References & Citations
[1]Zhang S, et al. Identification of novel GSPT1 degraders by virtual screening and bioassay. Eur J Med Chem. 2024 Jul 5;273:116524.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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