PFM39
PFM39, a Mirin analog, is a potent and selective MRE11 exonuclease inhibitor. PFM39 inhibits phosphate rotation for dsDNA exonuclease activity. PFM39 does not inhibit TmMre11 or human MRE11/MRN endonuclease activity[1].
Product Specifications
CAS Number
[1310744-67-2]
UNSPSC
12352005
Hazard Statement
H319
Target
Endonuclease
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pfm39.html
Purity
99.01
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N=C(N)S/C1=C\C2=CC=C(N)C=C2
Molecular Formula
C10H9N3OS
Molecular Weight
219.26
Precautions
H319
References & Citations
[1]Atsushi Shibata , et al. DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol Cell. 2014 Jan 9;53 (1) :7-18.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS637169-01 0.1 mg
Tie2, Fc Chimera, Recombinant, Rat (Tunica Internal Endothelial Cell Kinase, Angiopoietin1 Receptor, p140 Tek, Tyrosine Protein Kinase Receptor)
Ask
View Details 
MBS637169-02 5x 0.1 mg
Tie2, Fc Chimera, Recombinant, Rat (Tunica Internal Endothelial Cell Kinase, Angiopoietin1 Receptor, p140 Tek, Tyrosine Protein Kinase Receptor)
Ask
View Details 
MBS6131311-01 0.1 mL
FKBP5 (FK506-binding Protein 5, Peptidyl-prolyl cis-trans Isomerase FKBP5, PPIase FKBP5, Rotamase, HSP-binding Immunophilin, HBI, FKBP52 Protein, 51kD FK506-binding Protein, 51kD FKBP, FKBP-51, 54kD Progesterone Receptor-associated Immunophilin, FKBP54, p
Ask
View Details