PFM39

PFM39, a Mirin analog, is a potent and selective MRE11 exonuclease inhibitor. PFM39 inhibits phosphate rotation for dsDNA exonuclease activity. PFM39 does not inhibit TmMre11 or human MRE11/MRN endonuclease activity[1].

Product Specifications

CAS Number

[1310744-67-2]

UNSPSC

12352005

Hazard Statement

H319

Target

Endonuclease

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pfm39.html

Purity

99.01

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1N=C(N)S/C1=C\C2=CC=C(N)C=C2

Molecular Formula

C10H9N3OS

Molecular Weight

219.26

Precautions

H319

References & Citations

[1]Atsushi Shibata , et al. DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol Cell. 2014 Jan 9;53 (1) :7-18.