Buflomedil (hydrochloride)

Buflomedil hydrochloride, a vasodilator agent, is an orally active α1A-adrenoceptor antagonist with Kis of 4.06 µM and 6.84 µM for α1A-AR and α1B-AR, respectively. Buflomedil hydrochloride can be used for the study of peripheral circulatory disorders[1][2].

Product Specifications

CAS Number

[35543-24-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Buflomedil-hydrochloride.html

Purity

99.81

Solubility

DMSO : 33.33 mg/mL (ultrasonic) |H2O : ≥ 55 mg/mL

Smiles

O=C(C1=C(OC)C=C(OC)C=C1OC)CCCN2CCCC2.Cl

Molecular Formula

C17H26ClNO4

Molecular Weight

343.85

Precautions

H302, H315, H319, H335

References & Citations

[1]http://www.medscape.com/viewarticle/753768|[2]Tang LM, et al. Inhibitory effect of buflomedil on prostate alpha1A adrenoceptor in the Wistar rat. Neurosci Lett. 2004 Sep 2;367 (2) :224-7.