LC-MI-3
LC-MI-3 is an orally active and potent interleukin-1 receptor-associated kinase 4 (IRAK4) PROTAC degrader, with a DC50 of 47.3 nM. LC-MI-3 effectively inhibits the activation of downstream NF-κB signaling. LC-MI-3 can be used for the research of acute and chronic inflammatory skin. (Blue: VHL ligand, Black: linker, Pink: CRBN ligand ).
Product Specifications
UNSPSC
12352005
Target
IRAK; NF-κB; PROTACs
Type
Reference compound
Related Pathways
Immunology/Inflammation; NF-κB; PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/lc-mi-3.html
Smiles
O=C1N(C(C2=C1C=C(C=C2)C#CCOCCC(N3CCN(CC3)C4=CC=C(C(OC)=C4)NC(C5=CC=CC(C6=CC=NN6)=N5)=O)=O)=O)C7CCC(NC7=O)=O
Molecular Formula
C39H36N8O8
Molecular Weight
744.75
References & Citations
[1]Chen L, et al. Discovery of LC-MI-3: A Potent and Orally Bioavailable Degrader of Interleukin-1 Receptor-Associated Kinase 4 for the Treatment of Inflammatory Diseases. J Med Chem. 2024 May 23;67 (10) :8060-8076.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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