GPNA (hydrochloride)

GPNA hydrochloride is a well known substrate of the enzyme γ-glutamyltransferase (GGT) . GPNA hydrochloride is a specific glutamine (Gln) transporter ASCT2 inhibitor. GPNA hydrochloride also inhibit Na+-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na+-independent leucine transporters LAT1/2. GPNA reversibly induces apoptosis in A549 cells[1].

Product Specifications

CAS Number

[67953-08-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; ASCT

Type

Reference compound

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gpna-hydrochloride.html

Purity

99.91

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC([C@@H](N)CCC(NC1=CC=C([N+]([O-])=O)C=C1)=O)=O.[H]Cl

Molecular Formula

C11H14ClN3O5

Molecular Weight

303.70

Precautions

H302, H315, H319, H335

References & Citations

[1]Corti A, et al. γ-Glutamyltransferase enzyme activity of cancer cells modulates L-γ-glutamyl-p-nitroanilide (GPNA) cytotoxicity. Sci Rep. 2019 Jan 29;9 (1) :891.