3-Deoxysappanchalcone

3-Deoxysappanchalcone is a naturally-occurring chalcone compound found in Caesalpinia sappan L. (Leguminosae), which possesses anti-allergic, antiviral, anti-inflammatory and antioxidant activities. 3-Deoxysappanchalcone exerts anti-inflammatory activity via induce heme oxygenase-1 (HO-1) expression by activating the AKT/mTOR pathway in murine macrophages. 3-Deoxysappanchalcone also exhibits anti-influenza virus activity (H3N2, IC50 = 1.06 μM) [1][2].

Product Specifications

CAS Number

[112408-67-0]

UNSPSC

12352005

Target

Influenza Virus

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/3-deoxysappanchalcone.html

Purity

99.77

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(/C=C/C1=CC=C(C=C1)O)C2=CC=C(C=C2OC)O

Molecular Formula

C16H14O4

Molecular Weight

270.28

References & Citations

[1]Kim JH, et al. The anti-inflammatory effect of 3-deoxysappanchalcone is mediated by inducing heme oxygenase-1 via activating the AKT/mTOR pathway in murine macrophages. Int Immunopharmacol. 2014 Oct;22 (2) :420-6.|[2]Liu AL, et al. In vitro anti-influenza viral activities of constituents from Caesalpinia sappan. Planta Med. 2009 Mar;75 (4) :337-9.