Corynoline

Corynoline is a reversible and noncompetitive acetylcholinesterase (AChE) inhibitor with an IC50 of 30.6 μM[1]. Corynoline exhibits anti-inflammatory activity by activating Nrf2[2].

Product Specifications

CAS Number

[18797-79-0]

UNSPSC

12352005

Hazard Statement

H302+H312+H332

Target

Cholinesterase (ChE) ; Keap1-Nrf2

Type

Natural Products

Related Pathways

Neuronal Signaling; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/corynoline.html

Concentration

10mM

Purity

98.84

Solubility

DMSO : 40 mg/mL (ultrasonic)

Smiles

C[C@@]1(C(C=CC2=C3OCO2)=C3CN4C)[C@@]4([H])C(C=C(OCO5)C5=C6)=C6C[C@@H]1O

Molecular Formula

C21H21NO5

Molecular Weight

367.40

Precautions

H302+H312+H332

References & Citations

[1]Kim DK. Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase. Arch Pharm Res. 2002 Dec;25 (6) :817-9.|[2]Liu B, et al. Corynoline Exhibits Anti-inflammatory Effects in Lipopolysaccharide (LPS) -Stimulated Human Umbilical Vein Endothelial Cells through Activating Nrf2. Inflammation. 2018 Oct;41 (5) :1640-1647.