Xanthine oxidase-IN-15

Xanthine oxidase-IN-15 (Compound 6c) is a selective inhibitor of Xanthine oxidase (XO) (IC50=0.13 μM) . Xanthine oxidase-IN-15 inhibits XO catalysis by forming a stable interaction with the active site of XO. Xanthine oxidase-IN-15 is mainly used in the study of hyperuricemia and gout[1].

Product Specifications

CAS Number

[2982794-86-3]

UNSPSC

12352005

Target

Xanthine Oxidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/xanthine-oxidase-in-15.html

Solubility

10 mM in DMSO

Smiles

N#CC1=CN(C(C)C)C2=C1C=C(C3=CC(C(O)=O)=NO3)C=C2

Molecular Formula

C16H13N3O3

Molecular Weight

295.29

References & Citations

[1]Huang D, et al. Design, synthesis, and biological evaluation of 5- (1H-indol-5-yl) isoxazole-3-carboxylic acids as novel xanthine oxidase inhibitors. Eur J Med Chem. 2024 May 5;271:116443