Prolylrapamycin

Prolylrapamycin (21-Norrapamycin) is the derivative of Rapamycin (HY-10219) . Prolylrapamycin exhibits antifungal activity, that inhibits Candida albicans, Saccharomyces cerevisiae, and Fusarium oxysporum with MIC of 0.125-2 μg/mL[1].

Product Specifications

CAS Number

[156223-31-3]

Product Name Alternative

21-Norrapamycin

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Fungal

Type

Natural Products

Related Pathways

Anti-infection

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/prolylrapamycin.html

Smiles

O=C([C@@](CCC1)([H])N1C(C([C@@]2(O)[C@H](C)CC[C@@](O2)([H])C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C([C@H](OC)[C@H](O)/C(C)=C/[C@H]3C)=O)=O)=O)O[C@H]([C@H](C)C[C@H]4C[C@@H](OC)[C@H](O)CC4)CC3=O

Molecular Formula

C50H77NO13

Molecular Weight

900.15

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Wong GK, et al., Antifungal activities of rapamycin and its derivatives, prolylrapamycin, 32-desmethylrapamycin, and 32-desmethoxyrapamycin. J Antibiot (Tokyo) . 1998 May;51 (5) :487-91.