Bucindolol (hydrochloride)
Bucindolol hydrochloride is a β-adrenergic receptor antagonist with activity in preventing new-onset atrial fibrillation. Bucindolol hydrochloride can reduce heart rate and the occurrence of bradycardia in patients with heart failure and atrial fibrillation[1].
Product Specifications
CAS Number
70369-47-0
UNSPSC
12352005
Hazard Statement
H301
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/bucindolol-hydrochloride.html
Smiles
N#CC1=CC=CC=C1OCC(O)CNC(C)(C)CC2=CNC3=C2C=CC=C3.Cl
Molecular Formula
C22H26ClN3O2
Molecular Weight
399.91
Precautions
P264-P270-P330-P405-P501
References & Citations
[1]Liggett SB, et al. A polymorphism within a conserved beta (1) -adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure. Proc Natl Acad Sci U S A. 2006 Jul 25;103 (30) :11288-93.|[2]Dose-limiting, adverse event-associated bradycardia with β-blocker treatment of atrial fibrillation in the GENETIC-AF trial
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Frequently Asked Questions
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