Urea (Standard)

Urea (Standard) is the analytical standard of Urea. This product is intended for research and analytical applications. Urea is a powerful protein denaturant via both direct and indirect mechanisms[1]. A potent emollient and keratolytic agent[2]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[3]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.

Product Specifications

CAS Number

[57-13-6]

Product Name Alternative

Carbonyl diamide (Standard)

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Apoptosis; Carbonic Anhydrase; Endogenous Metabolite; ERK; Reference Standards

Type

Reference Standards

Related Pathways

Apoptosis; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Others; Stem Cell/Wnt

Field of Research

Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/urea-standard.html

Purity

99.87

Smiles

NC(N)=O

Molecular Formula

CH4N2O

Molecular Weight

60.06

Precautions

H315, H319, H335

References & Citations

[4]Michea L, et al., Cell cycle delay and apoptosis are induced by high salt and urea in renal medullary cells. Am J Physiol Renal Physiol. 2000 Feb;278 (2) :F209-18.|[5]Zhang Z, et al., High urea and NaCl carbonylate proteins in renal cells in culture and in vivo, and high urea causes 8-oxoguanine lesions in their DNA. Proc Natl Acad Sci U S A. 2004 Jun 22;101 (25) :9491-6. |[6]Prabhakar SS, et al., Urea inhibits inducible nitric oxide synthase in macrophage cell line. Am J Physiol. 1997 Dec;273 (6) :C1882-8. |[7]Yang XY, et al., ERK activation by urea in the renal inner medullary mIMCD3 cell line. Am J Physiol. 1999 Aug;277 (2) :F176-85.|[8]Ogino Y, et al., Effects of chronic, urea-induced osmotic diuresis on kidney weight and function in rats. Diabetologia. 1994 Mar;37 (3) :225-31.|[1]Bennion BJ, et al. The molecular basis for the chemical denaturation of proteins by urea. Proc Natl Acad Sci U S A. 2003 Apr 29;100 (9) :5142-7.|[2]Pan M, et al. Urea: a comprehensive review of the clinical literature. Dermatol Online J. 2013 Nov 15;19 (11) :20392.|[3]Wang H, et al. Urea. Subcell Biochem. 2014;73:7-29.