NEK7-IN-2
NEK7-IN-2 (compound 23) is a potent inhibitor of NLRP3-NEK7 interaction. NEK7-IN-2 can enhance the thermal stability of NEK7 and regulatie NLRP3 inflammasome assembly. NEK7-IN-2 inhibits IL-1β releases[1].
Product Specifications
UNSPSC
12352211
Target
NEKs; NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nek7-in-2.html
Smiles
FC1=C(NC(NC2=CC(C(F)(F)F)=C(CN3CCN(C)CC3)C=C2)=O)C=CC(C4=CC=C(NC(C)=O)N=C4)=C1
Molecular Formula
C27H28F4N6O2
Molecular Weight
544.54
References & Citations
[1]Wang L, et, al. Discovery of novel biaryl urea derivatives against IL-1β release with low toxicity based on NEK7 inhibitor. Eur J Med Chem. 2024 Dec 3:283:117125.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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