BuChE-IN-10
BuChE-IN-10 (compound 7p) is an inhibitor of BuChE (eqBuChE IC50 = 4.68 nM, huBuChE IC50 = 9.12 nM) . BuChE-IN-10 has anti-neuroinflammatory activity and exhibits high BBB permeability[1].
Product Specifications
UNSPSC
12352005
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/buche-in-10.html
Solubility
10 mM in DMSO
Smiles
COC1=C(/C=C/C2=CC(OC(N3CCCCC3)=O)=CC=C2)OC(C)=CC1=O
Molecular Formula
C21H23NO5
Molecular Weight
369.41
References & Citations
[1]Chuanyu Yu, et al. Novel anti-neuroinflammatory pyranone-carbamate derivatives as selective butyrylcholinesterase inhibitors for treating Chuanyu Yu, et al. Novel anti-neuroinflammatory pyranone-carbamate derivatives as selective butyrylcholinesterase inhibitors for treating Alzheimer's disease. J Enzyme Inhib Med Chem. 2024, 39, 1.disease. J Enzyme Inhib Med Chem. 2024, 39, 1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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