2,5-Di-tert-butylhydroquinone
2,5-Di-tert-butylhydroquinone (BHQ) (Compound 2), an indirect food additive, is a Sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) inhibitor with an IC50 of 400 nM. 2,5-Di-tert-butylhydroquinone disrupts the gating function of the residue Glu309 which prevents Ca2+ from reaching their binding site. 2,5-Di-tert-butylhydroquinone regulates the activity of 5-lipoxygenase and COX-2 (IC50: 1.8 and 14.1 μM for 5-LO and COX-2, respectively) [1][2].
Product Specifications
CAS Number
88-58-4
UNSPSC
12352005
Hazard Statement
H301, H317, H335, H410
Target
Calcium Channel; COX; Lipoxygenase
Type
Reference compound
Related Pathways
Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/2-5-di-tert-butylhydroquinone.html
Purity
99.90
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=CC(C(C)(C)C)=C(O)C=C1C(C)(C)C
Molecular Formula
C14H22O2
Molecular Weight
222.33
Precautions
H301, H317, H335, H410
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-LOX; COX-2
Available Sizes
Frequently Asked Questions
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