(-) -Isodocarpin

(-) -Isodocarpin (Isodocarpin), a diterpenoid, is a potent melanogenesis inhibitor with an IC50 of 0.19 μM in B16 4A5 cells. (-) -Isodocarpin inhibits the expression of tyrosinase, tyrosine-related protein (TRP) -1, and TRP-2 mRNA[1].

Product Specifications

CAS Number

[10391-08-9]

Product Name Alternative

Isodocarpin

UNSPSC

12352005

Target

Melanocortin Receptor

Type

Natural Products

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/minus-isodocarpin.html

Purity

99.78

Solubility

10 mM in DMSO

Smiles

O[C@H]1[C@@]2([H])[C@]3(CO1)[C@@]4([H])[C@@]5(C(O[C@@]3([H])CCC2(C)C)=O)C[C@@](C(C5=O)=C)([H])CC4

Molecular Formula

C20H26O5

Molecular Weight

346.42

References & Citations

[1]Yoshiaki Manse, et al. Melanogenesis Inhibitory Activity of Diterpenoid and Triterpenoid Constituents from the Aerial Part of Isodon trichocarpus. Natural Product Communications. August 1, 2017.