IEM-1925 (bromide)
IEM-1925 bromide is an orally active glutamate receptor antagonist, increases the latent period and decreases the duration of status epilepticus in rats in a lithium-pilocarpine model of epilepsy[1][2].
Product Specifications
CAS Number
[258282-23-4]
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/iem-1925-bromide.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NCCCCCNC1(C2=CC=CC=C2)CCCCC1.Br.Br
Molecular Formula
C17H30Br2N2
Molecular Weight
422.24
References & Citations
[1]D B Tikhonov, et al. Voltage-dependent block of native AMPA receptor channels by dicationic compounds. Br J Pharmacol. 2000 Jan;129 (2) :265-74.|[2]S. I. Vataev, et al. IEM-1925, a Glutamate Receptor Channel Blocker, Increases the Latent Period and Decreases the Duration of Status Epilepticus in Rats in a Lithium-Pilocarpine Model of Epilepsy. Neuroscience and Behavioral Physiology volume 51, pages976–984 (2021) .
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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