II-B08

II-B08 is a reversible and noncompetitive SHP2 inhibitor (IC50: 5.5 μM, 15.7, 14.3 μM for SHP2, SHP1, PTP1B) . II-B08 can be used for cancer research[1].

Product Specifications

CAS Number

[1143579-78-5]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

SHP1; SHP2

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ii-b08.html

Purity

95.00

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC2=C(N(C)C(C3=CC=CC=C3)=C2C4=CN(CCC(NC5=CC=C(C6=CC=CC=C6)C=C5)=O)N=N4)C=C1O)O

Molecular Formula

C33H27N5O4

Molecular Weight

557.60

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Zeng LF, et al. Therapeutic potential of targeting the oncogenic SHP2 phosphatase. J Med Chem. 2014 Aug 14;57 (15) :6594-609.|[2]Zhang X, et al. Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) . J Med Chem. 2010 Mar 25;53 (6) :2482-93.