AEM1

AEM1 is an Nrf2 inhibitor with anti-tumor and oral activity. AEM1 promotes the differentiation of HepaRG cells towards mature liver cells, aiding in the recovery of damaged liver[1][2].

Product Specifications

CAS Number

[1030123-90-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Keap1-Nrf2

Type

Reference compound

Related Pathways

NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/aem1.html

Purity

99.83

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC1=CC=C(C2=CSC3=NC=NC(NCC4=CC=C(OCO5)C5=C4)=C32)C=C1

Molecular Formula

C20H14FN3O2S

Molecular Weight

379.41

Precautions

H302, H315, H319, H335

References & Citations

[1]DeNicola GM, et al. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature. 2011 Jul 6;475 (7354) :106-9. |[2]Bollong MJ, Yun H, Sherwood L, Woods AK, Lairson LL, Schultz PG. A Small Molecule Inhibits Deregulated NRF2 Transcriptional Activity in Cancer. ACS Chem Biol. 2015 Oct 16;10 (10) :2193-8. |[3]Francesco Bellanti, et al. Inhibition of nuclear factor (erythroid-derived 2) -like 2 promotes hepatic progenitor cell activation and differentiation