JA2131
JA2131 is a small molecular inhibitor of Poly (ADP-ribose) Glycohydrolase (PARG) (IC50=0.4 μM) . JA2131 regulate DNA damage responses, causes replication fork stalling and cancer cell death[1][2].
Product Specifications
CAS Number
[6505-99-3]
UNSPSC
12352005
Target
Poly (ADP-ribose) Glycohydrolase (PARG)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ja2131.html
Purity
99.7
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(N1C)N(C)C2=C(N=C(SCCN3CCOCC3)N2)C1=S
Molecular Formula
C13H19N5O2S2
Molecular Weight
341.45
References & Citations
[1]Houl JH, et al. Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death. Nat Commun. 2019 Dec 11;10 (1) :5654. |[2]Brosey CA, et al. Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly (ADP-ribose) glycohydrolase (PARG) structures with inhibitors. Prog Biophys Mol Biol. 2021 Aug;163:171-186.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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