Guanosine-5'-triphosphate (disodium salt)

Guanosine 5'-triphosphate (5'-GTP) trisodium salt is a G protein (G proteins) signaling activator and a high-energy precursor in the biosynthesis of nucleotide units in DNA and RNA. Guanosine 5'-triphosphate trisodium salt can promote myogenic cell differentiation by upregulating miRNA (miR133a, miR133b) and myogenic regulatory factor expression, and by inducing human myogenic precursor cells to release exosomes containing guanosine molecules. Guanosine-5'-triphosphate disodium salt holds promise for research in biosynthesis and skeletal muscle regeneration[1][2].

Product Specifications

CAS Number

[56001-37-7]

Product Name Alternative

5'-GTP (disodium salt)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; MicroRNA

Type

Oligonucleotides

Related Pathways

Epigenetics; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/guanosine-5-triphosphate-disodium-salt.html

Concentration

100 mM * 17.63 mL in Water

Purity

99.98

Solubility

H2O : 62.5 mg/mL (ultrasonic)

Smiles

O=C1C2=C(N(C=N2)[C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(O)(OP(O)(O[Na])=O)=O)(O[Na])=O)O3)N=C(N)N1

Molecular Formula

C10H14N5Na2O14P3

Molecular Weight

567.14

Precautions

H302, H315, H319, H335

References & Citations

[1]Guanosine triphosphate.|[2]Pietrangelo T, et al. Extracellular Guanosine 5'-Triphosphate Induces Human Muscle Satellite Cells to Release Exosomes Stuffed With Guanosine. Front Pharmacol. 2018 Mar 16;9:152.