Rhamnose

Rhamnose (L-Rhamnose) is an orally active deoxysugar. Rhamnose can inhibit levels of pro-inflammatory interleukin and matrix metalloproteinases (MMPs) in skin aging models. Rhamnose can promote the phosphorylation levels of PKA substrates and HSL in SVF-derived adipocytes, stimulating PKA signaling. Rhamnose can act against obesity in mice by stimulating fat dopamine receptors and inducing thermogenesis. Rhamnose shows anti-aging effects. Rhamnose monohydrate can be used in the study of Ehrlich’s solid tumors and sarcomas[2][3][5].

Product Specifications

CAS Number

[3615-41-6]

Product Name Alternative

L-Rhamnose

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; Interleukin Related; MMP; PKA

Type

Natural Products

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; Stem Cell/Wnt; TGF-beta/Smad

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/l-mannomethylose.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C[C@@H]([C@@H]([C@H]([C@H](C)O)O)O)O

Molecular Formula

C6H12O5

Molecular Weight

164.16

Precautions

H302, H315, H319, H335

References & Citations

[1]Fieseler L, et al. Rhamnose-inducible gene expression in Listeria monocytogenes. PLoS One. 2012;7 (8) :e43444. |[2]Novotná R, et al. Hesperidin, Hesperetin, Rutinose, and Rhamnose Act as Skin Anti-Aging Agents. Molecules. 2023 Feb 11;28 (4) :1728. |[3]Lv S, et al. Rhamnose Displays an Anti-Obesity Effect Through Stimulation of Adipose Dopamine Receptors and Thermogenesis. Diabetes. 2023 Mar 1;72 (3) :326-335.|[4]Cham BE, et al. Selective cytotoxicity for cancer cells and inhibition of cytotoxicity by rhamnose in mice with sarcoma 180. Cancer Lett. 1990 Dec 17;55 (3) :221-5.|[5]Tomsik P, et al. L-rhamnose and L-fucose suppress cancer growth in mice[J]. Central European Journal of Biology, 2011, 6: 1-9.