CNS-11
CNS-11 is a blood-brain barrier permeable tau fibril-degrading compound. CNS-11 reduces α-synuclein. CNS-11 can be used in Alzheimer's and Parkinson's disease research[1][2].
Product Specifications
CAS Number
445218-34-8
UNSPSC
12352005
Target
Tau Protein; α-synuclein
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cns-11.html
Purity
98.88
Solubility
DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C2=C(C3=CC=C2)C(C4=CC=CC=C34)=NN1CC(NC(C(C)=CC(C)=C5)=C5C)=O
Molecular Formula
C25H21N3O2
Molecular Weight
395.45
References & Citations
[1]Paul M Seidler, et al. Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro. Nat Commun. 2022 Sep 16;13 (1) :5451. |[2]Murray KA, et al. Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils. Proc Natl Acad Sci U S A. 2023 Feb 14;120 (7) :e2217835120.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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