Tiotropium-d6 (bromide)

Tiotropium-d6 (bromide) is deuterium labeled Tiotropium (Bromide) . Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.

Product Specifications

CAS Number

[1126775-44-7]

Product Name Alternative

BA679 BR-d6

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Isotope-Labeled Compounds; mAChR

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Purity

94.59

Solubility

10 mM in DMSO

Smiles

[2H]C([2H])([2H])[N+]1(C([2H])([2H])[2H])[C@H](C2)[C@](O3)([H])[C@]3([H])[C@@H]1C[C@@H]2OC(C(C4=CC=CS4)(C5=CC=CS5)O)=O.[Br-]

Molecular Formula

C19H16D6BrNO4S2

Molecular Weight

478.45

Precautions

H302, H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Barnes PJ. Tiotropium bromide. Expert Opin Investig Drugs. 2001 Apr;10 (4) :733-40.|[3]Lipson DA. Tiotropium bromide. Int J Chron Obstruct Pulmon Dis. 2006;1 (2) :107-14.|[4]Mamary AJ, Criner GJ. Tiotropium bromide for chronic obstructive pulmonary disease. Expert Rev Respir Med. 2009 Jun;3 (3) :211-20.|[5]Szmidt M. [The influence of treatment with formoterol, formoterol with tiotropium, formoterol with inhaled glucocorticosteroid and tiotropium on lung functions, tolerance of exercise and simple, morning everyday activities in patients with chronic obstructive pulmonary disease (COPD) ]. Pneumonol Alergol Pol. 2012;80 (3) :255-62.|[6]ZuWallack AR, ZuWallack RL. Tiotropium bromide, a new, once-daily inhaled anticholinergic bronchodilator for chronic-obstructive pulmonary disease. Expert Opin Pharmacother. 2004 Aug;5 (8) :1827-35.