Quazinone
Quazinone is a selective inhibitor of cGMP-inhibited-phosphodiesterase (cGI-PDE, PDE3) . Quazinone inhibits the phosphorylation of p42/p44 MAP kinase. Quazinone possesses antimitogenic effect [1].
Product Specifications
CAS Number
70018-51-8
Product Name Alternative
Ro 13-6438; Ro 13-6438/006
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MAPKAPK2 (MK2) ; Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/quazinone.html
Purity
99.7
Solubility
10 mM in DMSO
Smiles
C[C@H]1N2C(NC3=CC=CC(Cl)=C3C2)=NC1=O
Molecular Formula
C11H10ClN3O
Molecular Weight
235.67
Precautions
H302, H315, H319, H335
References & Citations
[1]A Taher, et al. Characterization of cyclic nucleotide phosphodiesterase isoenzymes in the human ureter and their functional role in vitro. World J Urol. 1994;12 (5) :286-91.|[2]M T Osinski, et al. Inhibition of platelet-derived growth factor-induced mitogenesis by phosphodiesterase 3 inhibitors: role of protein kinase A in vascular smooth muscle cell mitogenesis. Biochem Pharmacol. 2000 Aug 1;60 (3) :381-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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