RIPK1-IN-25
RIPK1-IN-25 (WL8) is a blood-brain permeable RIPK1 inhibitor with EC50 and Kd values are 19.9 and 25 nM, respectively. RIPK1-IN-25 can be used in the study of neurometabolic diseases[1].
Product Specifications
UNSPSC
12352005
Target
RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ripk1-in-25.html
Smiles
CC1=C(F)C=C(C2CC=NN2C(C3CCN(C(C4=CC=CC(F)=N4)=O)CC3)=O)C=C1
Molecular Formula
C22H22F2N4O2
Molecular Weight
412.43
References & Citations
[1]Li W, et al. Structure-based discovery of a 4,5-Dihydropyrazole-cored PET ligand for imaging of receptor-interacting serine/threonine-protein kinase 1 (RIPK1) in the brain. Eur J Med Chem. 2024 Sep 2;279:116803.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RIPK1
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