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RIPK1-IN-25

RIPK1-IN-25 (WL8) is a blood-brain permeable RIPK1 inhibitor with EC50 and Kd values are 19.9 and 25 nM, respectively. RIPK1-IN-25 can be used in the study of neurometabolic diseases[1].

Product Specifications

UNSPSC

12352005

Target

RIP kinase

Type

Reference compound

Related Pathways

Apoptosis

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ripk1-in-25.html

Smiles

CC1=C(F)C=C(C2CC=NN2C(C3CCN(C(C4=CC=CC(F)=N4)=O)CC3)=O)C=C1

Molecular Formula

C22H22F2N4O2

Molecular Weight

412.43

References & Citations

[1]Li W, et al. Structure-based discovery of a 4,5-Dihydropyrazole-cored PET ligand for imaging of receptor-interacting serine/threonine-protein kinase 1 (RIPK1) in the brain. Eur J Med Chem. 2024 Sep 2;279:116803.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

RIPK1

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