KIF18A-IN-15
KIF18A-IN-15 (Compound Example 36) is a KIF18A inhibitor, available in two forms, EX36-A and its enantiomer EX36-B, with IC50s of 0.01-0.1 μM, respectively. EX36-A and EX36-B inhibit OVCAR-3 cells viability with IC50s of 0.01-0.1 μM and 0-0.01 μM, respectively. KIF18A-IN-15 can be used in tumor (e.g. colon, breast, lung) studies[1].
Product Specifications
CAS Number
[3051552-64-5]
UNSPSC
12352005
Target
Kinesin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kif18a-in-15.html
Smiles
O=C1NC2=CC(C)=N/C(N2)=N/CC(COCC3(C(F)(F)F)CCN(CC3)C4=CC(NS(=O)(CCO)=O)=CC=C14)C
Molecular Formula
C25H33F3N6O5S
Molecular Weight
586.63
References & Citations
[1]Ding, et al. Inhibitors of kif18a and uses thereof. WO2024153217.WIPO, 2024-01-19.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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