KIF18A-IN-15
Product Specifications
UNSPSC Description
KIF18A-IN-15 (Compound Example 36) is a KIF18A inhibitor, available in two forms, EX36-A and its enantiomer EX36-B, with IC50s of 0.01-0.1 μM, respectively. EX36-A and EX36-B inhibit OVCAR-3 cells viability with IC50s of 0.01-0.1 μM and 0-0.01 μM, respectively. KIF18A-IN-15 can be used in tumor (e.g. colon, breast, lung) studies[1].
Target Antigen
Kinesin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Cytoskeleton
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kif18a-in-15.html
Smiles
O=C1NC2=CC(C)=N/C(N2)=N/CC(COCC3(C(F)(F)F)CCN(CC3)C4=CC(NS(=O)(CCO)=O)=CC=C14)C
Molecular Weight
586.63
References & Citations
[1]Ding, et al. Inhibitors of kif18a and uses thereof. WO2024153217.WIPO, 2024-01-19.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-164979/KIF18A-IN-15-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-164979/
Clinical Information
No Development Reported
CAS Number
3051552-64-5
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