AVE 0991 (sodium salt)
Product Specifications
UNSPSC Description
AVE 0991 sodium salt is a nonpeptide and orally active Ang-(1-7) receptor Mas agonist. AVE 0991 competes for high-affinity binding of [125I]-Ang-(1-7) to bovine aortic endothelial cell membranes with IC50 of 21 nM[1].
Target Antigen
Angiotensin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/AVE-0991-sodium-salt.html
Solubility
DMSO : ≥ 55 mg/mL|H2O : 50 mg/mL (ultrasonic)
Smiles
O=S(C1=C(C2=CC=C(CN3C(C=O)=C(OC)N=C3C4=CC=CC=C4)C=C2)C=C(CC(C)C)S1)([N-]C(NCC)=O)=O.[Na+]
Molecular Weight
602.70
References & Citations
[1]Wiemer G, et al. AVE 0991, a nonpeptide mimic of the effects of angiotensin-(1-7) on the endothelium. Hypertension. 2002 Dec;40(6):847-52.|[2]Pinheiro SV, et al. Nonpeptide AVE 0991 is an angiotensin-(1-7) receptor Mas agonist in the mouse kidney. Hypertension. 2004 Oct;44(4):490-6.|[3]Ferreira AJ, et al. The nonpeptide angiotensin-(1-7) receptor Mas agonist AVE-0991 attenuates heart failure induced by myocardial infarction. Am J Physiol Heart Circ Physiol. 2007 Feb;292(2):H1113-9.Blood. 2015 Jan 22;125(4):710-9.|Aging (Albany NY). 2018 Apr 17;10(4):645-657. |Biochem Pharmacol. 2024 May 3:224:116261.|Diabetes. 2017 Aug;66(8):2201-2212. |Exp Anim. 2022 Aug 8.|Front Aging Neurosci. 2021 Feb 15.|J Hepatol. 2022 Nov 9;S0168-8278(22)03285-8.|J Inflamm Res. 2021 Dec 18;14:7007-7019.|PLoS One. 2015 Nov 5;10(11):e0142087.|Redox Biol. 2019 Jan;20:75-86.|Res Sq. 2024 Aug 10.|Research Square Preprint. 2021 Nov.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15778A/AVE-0991-sodium-salt-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15778A/AVE-0991-sodium-salt-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
306288-04-0
Available Sizes
Curated Selection
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