AVE 0991 (sodium salt)

AVE 0991 sodium salt is a nonpeptide and orally active Ang- (1-7) receptor Mas agonist. AVE 0991 competes for high-affinity binding of [125I]-Ang- (1-7) to bovine aortic endothelial cell membranes with IC50 of 21 nM[1].

Product Specifications

CAS Number

[306288-04-0]

UNSPSC

12352005

Target

Angiotensin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/AVE-0991-sodium-salt.html

Concentration

10mM

Purity

99.47

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

O=S(C1=C(C2=CC=C(CN3C(C=O)=C(OC)N=C3C4=CC=CC=C4)C=C2)C=C(CC(C)C)S1)([N-]C(NCC)=O)=O.[Na+]

Molecular Formula

C29H31N4NaO5S2

Molecular Weight

602.70

References & Citations

[1]Wiemer G, et al. AVE 0991, a nonpeptide mimic of the effects of angiotensin- (1-7) on the endothelium. Hypertension. 2002 Dec;40 (6) :847-52.|[2]Pinheiro SV, et al. Nonpeptide AVE 0991 is an angiotensin- (1-7) receptor Mas agonist in the mouse kidney. Hypertension. 2004 Oct;44 (4) :490-6.|[3]Ferreira AJ, et al. The nonpeptide angiotensin- (1-7) receptor Mas agonist AVE-0991 attenuates heart failure induced by myocardial infarction. Am J Physiol Heart Circ Physiol. 2007 Feb;292 (2) :H1113-9.