PROTAC IRAK4 degrader-3

PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau[1].

Product Specifications

CAS Number

[2374122-43-5]

UNSPSC

12352005

Target

IRAK; PROTACs

Type

Reference compound

Related Pathways

Immunology/Inflammation; PROTAC

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/protac-irak4-degrader-3.html

Purity

97.22

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC[C@H]([C@@H](C(N1)=O)F)[C@H]1COC2=NC=C(C#CCN3CCC4(CCN(C5=NC=C(C(N[C@H](C(C)(C)C)C(N6[C@H](C[C@@H](C6)O)C(NCC7=CC=C(C8=C(N=CS8)C)C=C7)=O)=O)=O)C=N5)CC4)CC3)C9=C2C=C(OC)C(C(N)=O)=C9

Molecular Formula

C57H68FN11O8S

Molecular Weight

1086.28

References & Citations

[1]Nunes J, et al. Targeting IRAK4 for Degradation with PROTACs. ACS Med Chem Lett. 2019;10 (7) :1081-1085. Published 2019 Jun 14.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

IRAK4

Available Sizes

Curated Selection

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