Dansylcadaverine

Dansylcadaverine (Monodansyl cadaverine) is an autofluorescent compound used for the labeling of autophagic vacuoles. Dansylcadaverine, a high affinity substrate of transglutaminases, can block the receptor-mediated endocytosis of many ligands[1][2].

Product Specifications

CAS Number

[10121-91-2]

Product Name Alternative

Monodansyl cadaverine

UNSPSC

12171500

Hazard Statement

H302, H315, H319, H335

Target

Autophagy

Type

Dye Reagents

Related Pathways

Autophagy

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/Dansylcadaverine.html

Purity

98.80

Solubility

DMSO : 62.5 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

NCCCCCNS(=O)(C1=CC=CC2=C1C=CC=C2N(C)C)=O

Molecular Formula

C17H25N3O2S

Molecular Weight

335.46

Precautions

H302, H315, H319, H335

References & Citations

[1]Huff T, et al. Thymosin beta (4) serves as a glutaminyl substrate of transglutaminase. Labeling with fluorescentdansylcadaverine does not abolish interaction with G-actin. FEBS Lett. 1999 Dec 24;464 (1-2) :14-20.|[2]Laha D, et al. Interplay between autophagy and apoptosis mediated by copper oxide nanoparticles in human breast cancer cells MCF7. Biochim Biophys Acta. 2014 Jan;1840 (1) :1-9.|[3]Gao L, et al. Autophagy blockade sensitizes human head and neck squamous cell carcinoma towards CYT997 through enhancing excessively high reactive oxygen species-induced apoptosis. J Mol Med (Berl) . 2018;96 (9) :929-938.|[4]Cornwell MM, et al. Inhibition of the adhesion of Chinese hamster ovary cells by the naphthylsulfonamides dansylcadaverine and N- (6-aminohexyl) -5-chloro-1-naphthylenesulfonamide (W7) . Biochim Biophys Acta. 1983;762 (3) :414-419.|[5]David SA, et al. Analysis of the binding of polymyxin B to endotoxic lipid A and core glycolipid using a fluorescent displacement probe. Biochim Biophys Acta. 1992;1165 (2) :147-152.