BAY-204

BAY-204 (BRD3727) is a potent, ATP-competitive, and selective CSNK1α inhibitor (IC50 = 2 nM at 10 μM ATP; 12 nM at 1 mM ATP) . BAY-204 can be used for the study of acute myeloid leukemia (AML) [1][2].

Product Specifications

CAS Number

[2468784-57-6]

Product Name Alternative

BRD3727

UNSPSC

12352005

Target

Casein Kinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bay-204.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C2=C(NC(C3=CC=NC(NC([C@@H](CC(F)F)C4=CC=C(F)C=C4)=O)=C3)=C2NC5=CC=CC=C5)CCN1C

Molecular Formula

C29H26F3N5O2

Molecular Weight

533.54

References & Citations

[1]Volker Schulze, et al. 3-amino-2-[2- (acylamino) pyridin-4-yl]-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-c]pyridin-4-one as csnk1 inhibitors. WO2020161257 A1. |[2]Steven M. Corsello, et al. Abstract 3588: Discovery of potent and selective CSNK1A1 inhibitors for solid tumor therapy.