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Dermatan (sulphate sodium)

Dermatan sulphate sodium is an oral active glycosaminoglycan and thrombin inactivator with antithrombotic activity. It selectively catalyzes the heparin cofactor II-mediated inactivation of thrombin without interacting with antithrombin III. Dermatan sulphate sodium promotes stem cell differentiation, exhibits high bioavailability, and alleviates pulmonary fibrosis injury induced by Bleomycin. Dermatan sulphate sodium can be used in research related to cardiovascular diseases, inflammation, and stem cell differentiation[1][2][3].

Product Specifications

CAS Number

54328-33-5

UNSPSC

12352100

Target

Thrombin

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/dermatan-sulphate-sodium.html

Purity

95.4

Solubility

DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 100 mg/mL (ultrasonic)

References & Citations

[1]Nenci GG. Dermatan sulphate as an antithrombotic drug. Pathophysiol Haemost Thromb. 2002 Sep-Dec;32 (5-6) :303-7. |[2]Xu J, et al. Effect of dermatan sulphate on a C57-mouse model of pulmonary fibrosis. J Int Med Res. 2019 Jun;47 (6) :2655-2665.|[3]Ogura C, et al. Dermatan sulphate promotes neuronal differentiation in mouse and human stem cells. J Biochem. 2021 Feb 6;169 (1) :55-64.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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