Z-WEHD-FMK

Z-WEHD-FMK is a potent, cell-permeable and irreversible caspase-1/5 inhibitor. Z-WEHD-FMK also exhibits a robust inhibitory effect on cathepsin B activity (IC50=6 μM) . Z-WEHD-FMK can be used to investigate cells for evidence of apoptosis[1][2][4].

Product Specifications

CAS Number

[210345-00-9]

Product Name Alternative

Z-WE (OMe) HD (OMe) -FMK

UNSPSC

12352209

Target

Caspase; Cathepsin

Type

Peptides

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/z-wehd-fmk.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](CCC(OC)=O)C(N[C@H](C(N[C@H](C(CF)=O)CC(OC)=O)=O)CC1=CN=CN1)=O)[C@@H](NC(OCC2=CC=CC=C2)=O)CC3=CNC4=C3C=CC=C4

Molecular Formula

C37H42FN7O10

Molecular Weight

763.77

References & Citations

[1]Kamada S, et al. Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases.Cell Death Differ. 1997 Aug;4 (6) :473-8.|[2]Yang D, et al. Sensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish.Nat Commun. 2018 Aug 3;9 (1) :3052.|[3]Ferko MA, et al. Effects of metal ions on caspase-1 activation and interleukin-1β release in murine bone marrow-derived macrophages.PLoS One. 2018 Aug 23;13 (8) :e0199936.|[4]Newman ZL, et al. CA-074Me protection against anthrax lethal toxin.Infect Immun. 2009 Oct;77 (10) :4327-36.