Endothelin B Receptor rabbit pAb
The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016],
Product Specifications
Background
UniProt
P24530
Swiss Prot
P24530
Reactivity
Human; Rat; Mouse
Immunogen
Synthetic Peptide of Endothelin B Receptor AA range: 270-350
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF
Concentration
1 mg/ml
Dilution
IHC 1:100-200
Molecular Weight
50kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
50kD
Fragment
IgG
Subcellular Location
Cell membrane ; Multi-pass membrane protein. internalized after activation by endothelins. .
Other Product Names
Endothelin B receptor (ET-B; ET-BR; Endothelin receptor non-selective type)
Gene ID (Human)
1910
Available Sizes
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