Alpha-Bisabolol

Alpha-Bisabolol, an orally active sesquiterpene alcohol, induces cell cycle arrest, mitochondrial apoptosis and inhibition of PI3K/Akt signalling pathways. alpha-Bisabolol exerts a protective action against Cisplatin (HY-17394) -induced nephrotoxicity by mitigating inflammation and oxidative stress through the inhibition of NFκB activation. alpha-Bisabolol exhibits anti-inflammatory, analgesic, antibiotic and anticancer activities[1][2].

Product Specifications

CAS Number

[515-69-5]

UNSPSC

12352211

Hazard Statement

H302, H311, H319, H413

Target

Apoptosis; PI3K

Type

Natural Products

Related Pathways

Apoptosis; PI3K/Akt/mTOR

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/alpha-bisabolol.html

Purity

80.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C/C(C)=C\CC[C@@](O)([C@@H]1CCC(C)=CC1)C

Molecular Formula

C15H26O

Molecular Weight

222.37

Precautions

H302, H311, H319, H413

References & Citations

[1]Wu S, et al. Anticancer effects of α-Bisabolol in human non-small cell lung carcinoma cells are mediated via apoptosis induction, cell cycle arrest, inhibition of cell migration and invasion and upregulation of P13K/AKT signalling pathway. J BUON. 2018 Sep-Oct;23 (5) :1407-1412.|[2]Nur Elena Zaaba, et al. The Nephroprotective Effects of α-Bisabolol in Cisplatin-Induced Acute Kidney Injury in Mice. Biomedicines. 2022 Apr 3;10 (4) :842.