Ulipristal acetate-d3

Ulipristal acetate-d3 (CDB-2914-d3) is deuterium labeled Ulipristal acetate. Ulipristal acetate (CDB-2914) is an orally active, selective progesterone receptor modulator (SPRM) . Ulipristal acetate stimulates the autophagic response selectively in leiomyoma cells. Ulipristal acetate has the potential for benign gynecological conditions treatment, such as uterine myoma[1][2][3].

Product Specifications

CAS Number

[1621894-62-9]

Product Name Alternative

CDB-2914-d3

UNSPSC

12352005

Target

Autophagy; Isotope-Labeled Compounds; Progesterone Receptor

Type

Isotope-Labeled Compounds

Related Pathways

Autophagy; Others; Vitamin D Related/Nuclear Receptor

Field of Research

Endocrinology; Cancer

Smiles

[2H]C([2H])(N(C1=CC=C([C@H]2C[C@@]3(C)[C@H]([C@H]4C2=C5CCC(C=C5CC4)=O)CC[C@]3(OC(C)=O)C(C)=O)C=C1)C)[2H]

Molecular Formula

C30H34D3NO4

Molecular Weight

478.64

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Jadav SP, et al. Ulipristal acetate, a progesterone receptor modulator for emergency contraception. J Pharmacol Pharmacother. 2012 Apr;3 (2) :109-11.|[3]Del Bello B, et al. Autophagy up-regulation by ulipristal acetate as a novel target mechanism in the treatment of uterine leiomyoma: an in vitro study. Fertil Steril. 2019 Dec;112 (6) :1150-1159.|[4]Hild SA, et al. CDB-2914: anti-progestational/anti-glucocorticoid profile and post-coital anti-fertility activity in rats and rabbits. Hum Reprod. 2000 Apr;15 (4) :822-9.|[5]Ciarmela P, et al. Ulipristal acetate modulates the expression and functions of activin a in leiomyoma cells. Reprod Sci. 2014 Sep;21 (9) :1120-5.|[6] Attardi BJ, et al. In vitro antiprogestational/antiglucocorticoid activity and progestin and glucocorticoid receptor binding of the putative metabolites and synthetic derivatives of CDB-2914, CDB-4124, and mifepristone. J Steroid Biochem Mol Biol.|[7]Pohl O, et al. Carcinogenicity and chronic rodent toxicity of the selective progesterone receptor modulator ulipristal acetate. Curr Drug Saf. 2013 Apr;8 (2) :77-97.|[8]Pohl O, et al. A 39-week oral toxicity study of ulipristal acetate in cynomolgus monkeys. Regul Toxicol Pharmacol. 2013 Jun;66 (1) :6-12.