Iclaprim
Iclaprim is a new selective bacterial Dihydrofolate inhibitor, which can inhibit the growth of S. aureus (MRSA) with an MIC90 of 0.06 μg/mL.
Product Specifications
CAS Number
[192314-93-5]
Product Name Alternative
AR-100
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/Iclaprim.html
Purity
98.92
Solubility
DMSO : 30 mg/mL (ultrasonic; warming)
Smiles
NC1=NC=C(CC2=C3C=CC(C4CC4)OC3=C(OC)C(OC)=C2)C(N)=N1
Molecular Formula
C19H22N4O3
Molecular Weight
354.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Schneider P, et al. Iclaprim, a novel diaminopyrimidine with potent activity on trimethoprim sensitive and resistant bacteria. Bioorg Med Chem Lett. 2003 Dec 1;13 (23) :4217-21.|[2]Kohlhoff SA, et al. Iclaprim. Expert Opin Investig Drugs. 2007 Sep;16 (9) :1441-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
Curated Selection
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