GW406108X

GW406108X is a specific Kif15 (Kinesin-12) inhibitor with an IC50 of 0.82 uM in ATPase assays. GW406108X, a potent autophagy inhibitor, shows ATP competitive inhibition against ULK1 with a pIC50 of 6.37 (427 nM) . GW406108X inhibits ULK1 kinase activity and blocks autophagic flux, without affecting the upstream signaling kinases mTORC1 and AMPK[1][2].

Product Specifications

CAS Number

[1644443-92-4]

Product Name Alternative

GW108X

UNSPSC

12352005

Target

Autophagy; Kinesin; ULK

Type

Reference compound

Related Pathways

Autophagy; Cell Cycle/DNA Damage; Cytoskeleton

Applications

COVID-19-immunoregulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gw406108x.html

Purity

98.0

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1NC2=C(C=C(C(C3=CC=CO3)=O)C=C2)/C1=C/C4=CC(Cl)=C(O)C(Cl)=C4

Molecular Formula

C20H11Cl2NO4

Molecular Weight

400.21

References & Citations

[1]Zachari M, et al. The identification and characterisation of autophagy inhibitors from the published kinase inhibitor sets. Biochem J. 2020;477 (4) :801-814.|[2]Dumas ME, et al. Dual inhibition of Kif15 by oxindole and quinazolinedione chemical probes. Bioorg Med Chem Lett. 2019;29 (2) :148-154.