EGFR WT/T790M-IN-1
EGFR WT/T790M-IN-1 (Compound 16h) is a dual EGFR WT and EGFR T790 inhibitor. EGFR WT/T790M-IN-1 can arrest the cell cycle in G2/M phase and induce apoptosis. EGFR WT/T790M-IN-1 has anti-cancer activity[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; EGFR
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-wt-t790m-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=COC(C2=NC(C3=CC(OC)=C(OC)C(OC)=C3)=NC=C2)=N1)NC4=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C4
Molecular Formula
C23H18N6O9
Molecular Weight
522.42
References & Citations
[1]Raghunath Khedkar N, et al. Computational Design, Synthesis, and Bioevaluation of 2- (Pyrimidin-4-yl) oxazole-4-carboxamide Derivatives: Dual Inhibition of EGFRWT and EGFRT790M with ADMET Profiling. Bioorg Chem. 2024 Feb;143:107027.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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