Entospletinib

Entospletinib (GS-9973) is an orally bioavailable, selective Syk inhibitor with an IC50 of 7.7 nM.

Product Specifications

CAS Number

[1229208-44-9]

Product Name Alternative

GS-9973

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Syk

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/GS-9973.html

Purity

99.49

Solubility

DMSO : 35 mg/mL (ultrasonic)

Smiles

C12=NC=CN1C=C(C3=CC4=C(C=C3)C=NN4)N=C2NC5=CC=C(N6CCOCC6)C=C5

Molecular Formula

C23H21N7O

Molecular Weight

411.46

Precautions

H315, H319, H320

References & Citations

[1]Currie KS, et al. Discovery of GS-9973, a Selective and Orally Efficacious Inhibitor of Spleen Tyrosine Kinase. J Med Chem. 2014 May 8;57 (9) :3856-73.|[2]Burke RT, et al. A potential therapeutic strategy for chronic lymphocytic leukemia by combining Idelalisib and GS-9973, a novel spleen tyrosine kinase (Syk) inhibitor. Oncotarget. 2014 Feb 28;5 (4) :908-15.