Fibrostat
Product Specifications
UNSPSC Description
Fibrostat (Compound 5n) is a selective HDAC6 inhibitor that exerts antifibrotic effects by inhibiting HDAC6 activity, with an IC50 value of 63 nM. It also exhibits good selectivity over HDAC1, HDAC3, HDAC5, HDAC8, HDAC10, and HDAC11. Fibrostat significantly downregulates fibrotic markers (fibronectin and collagen 1) in fibroblasts. Additionally, Fibrostat demonstrated no toxicity in rat-perfused heart and zebrafish larvae models. Fibrostat shows potential for research into fibrosis-related diseases[1].
Target Antigen
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/fibrostat.html
Smiles
O=C(N1CCC2(CC3=CC=CC=C3CN2CC4=CC=CC=C4)CC1)NCC5=CC=C(C=C5)C(NO)=O
Molecular Weight
484.59
References & Citations
[1]Fontana A, et al. Spirotetrahydroisoquinoline-Based Histone Deacetylase Inhibitors as New Antifibrotic Agents: Biological Evaluation in Human Fibroblasts from Bronchoalveolar Lavages of Idiopathic Pulmonary Fibrosis Patients[J]. ACS Pharmacology & Translational Science, 2024.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-169940/Fibrostat-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-169940/
Clinical Information
No Development Reported
Curated Selection
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