PDK-IN-1
PDK-IN-1 (compound 7o) is a pyruvate dehydrogenase kinase (PDK) inhibitor. PDK-IN-1 shows IC50 values of 0.03 and 0.1 μM for PDK1 and HSP90, respectively. PDK-IN-1 targets PDH/PDK axis thus reducing efficiently the tumor mass[1].
Product Specifications
CAS Number
[2897696-10-3]
UNSPSC
12352005
Target
HSP; PDHK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pdk-in-1.html
Purity
99.74
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
BrC1=CC(C(C2=C(C3=CNC4=C3C=C(OC)C=C4)N=NC(N)=N2)=CN5C)=C5N=C1
Molecular Formula
C20H16BrN7O
Molecular Weight
450.29
References & Citations
[1]Pecoraro C, et al. 1,2,4-Amino-triazine derivatives as pyruvate dehydrogenase kinase inhibitors: Synthesis and pharmacological evaluation. Eur J Med Chem. 2023 Mar 5;249:115134.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6356067-01 0.2 mL
TM55B, CT (TMEM55B, C14orf9, Transmembrane protein 55B, PtdIns-4,5-P2 4-Ptase I, Type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase) (FITC)
Ask
View Details MBS6356067-02 5x 0.2 mL
TM55B, CT (TMEM55B, C14orf9, Transmembrane protein 55B, PtdIns-4,5-P2 4-Ptase I, Type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase) (FITC)
Ask
View Details