PDK-IN-1

PDK-IN-1 (compound 7o) is a pyruvate dehydrogenase kinase (PDK) inhibitor. PDK-IN-1 shows IC50 values of 0.03 and 0.1 μM for PDK1 and HSP90, respectively. PDK-IN-1 targets PDH/PDK axis thus reducing efficiently the tumor mass[1].

Product Specifications

CAS Number

[2897696-10-3]

UNSPSC

12352005

Target

HSP; PDHK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pdk-in-1.html

Purity

99.74

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

BrC1=CC(C(C2=C(C3=CNC4=C3C=C(OC)C=C4)N=NC(N)=N2)=CN5C)=C5N=C1

Molecular Formula

C20H16BrN7O

Molecular Weight

450.29

References & Citations

[1]Pecoraro C, et al. 1,2,4-Amino-triazine derivatives as pyruvate dehydrogenase kinase inhibitors: Synthesis and pharmacological evaluation. Eur J Med Chem. 2023 Mar 5;249:115134.