Formycin triphosphate

Formycin triphosphate is a fluorescent analogue of ATP which on binding to enzyme active sites exhibits enhanced fluorescence. Formycin triphosphate is an ATP-competitive chicken liver pyruvate carboxylase inhibitor. Formycin triphosphate potentiates atrial natriuretic factor (ANF) -stimulated guanylate cyclase activity with an EC50 at about 90 μM and inhibits ATP-stimulated guanylate cyclase activity with an IC50 at about 100 μM[1][2].

Product Specifications

CAS Number

[16409-13-5]

UNSPSC

12352005

Target

Guanylate Cyclase

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/formycin-triphosphate.html

Smiles

NC1=C2C(C([C@@H]3O[C@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)[C@@H](O)[C@H]3O)=NN2)=NC=N1

Molecular Formula

C10H16N5O13P3

Molecular Weight

507.18

References & Citations

[1]P V Attwood, et al. Interaction of formycin A-5'-triphosphate with pyruvate carboxylase. FEBS Lett. 1984 Sep 17;175 (1) :45-50.|[2]C H Chang, et al. Formycin triphosphate as a probe for the ATP binding site involved in the activation of guanylate cyclase. Eur J Pharmacol. 1992 Oct 1;227 (2) :229-31.