93-O17S

93-O17S is an ionizable lipid. 93-O17S is involved in the construction of LNP. 93-O17S can achieve mRNA delivery to the spleen[1][2].

Product Specifications

CAS Number

[2227008-67-3]

UNSPSC

12352005

Hazard Statement

H225, H319

Target

Liposome

Type

Oligonucleotides

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/93-o17s.html

Concentration

10mM

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic) |Ethanol : ≥ 100 mg/mL

Smiles

O=C(CCN(CCCN1C=NC=C1)CCC(OCCSCCCCCCCCCCCCCC)=O)OCCSCCCCCCCCCCCCCC

Molecular Formula

C44H83N3O4S2

Molecular Weight

782.28

Precautions

H225, H319

References & Citations

[1]Omo-Lamai S, et al. Lipid Nanoparticle-Associated Inflammation is Triggered by Sensing of Endosomal Damage: Engineering Endosomal Escape Without Side Effects. bioRxiv [Preprint]. 2024 Apr 18:2024.04.16.589801.|[2]Delehedde C, et al. Intracellular Routing and Recognition of Lipid-Based mRNA Nanoparticles. Pharmaceutics. 2021 Jun 24;13 (7) :945.